楊博士和她的研究人員研究了紐約57個縣的5034名母親以及她們在2008年至2010年間出生的6171名孩子。在他們的童年中期，有2056名兒童參加了后續(xù)問卷調(diào)查，以了解是否有哮喘或任何過敏癥堅持。任何母親都接受過的生育治療，包括體外受精和排*誘導(dǎo)（通過口服或注射）。

　　這項研究表明，生育治療之間的共同生物學(xué)結(jié)果與使用這些治療所孕育的兒童發(fā)展為哮喘之間存在潛在聯(lián)系。盡管機制尚不清楚，但研究人員推測這可能導(dǎo)致受孕胎兒的激素水平超出正常生理范圍。然而，研究人員還推測，那些接受生育治療的母親可能更有可能*表孩子接受醫(yī)生的診斷。這可能是由于他們較高的社會經(jīng)濟背景，或者因為他們以前接受過生育治療而更有可能尋求醫(yī)療護理。

　　“在我們更好地了解潛在機制之前，對臨床實踐的影響是有限的，”該研究的第一作者Kristen Polinski博士告訴Healio。

　　作者建議需要進行額外的研究，這些研究對于得出生育治療或父母不孕癥如何可能導(dǎo)致他們的孩子患哮喘和過敏癥的風(fēng)險更高的結(jié)論是必要的。

　　Children born to women who underwent fertility treatment are associated with an increased risk of developing asthma,eczema,and other related allergies,despite their parental predisposition.

　　A study published in Human Reproduction has determined that children whose mothers'received fertility treatment,were 55 percent more likely to have a persistent wheeze at age three than their naturally-conceived peers.By seven to nine years of age,children were 56 percent more likely to develop asthma verified by a physician.Moreover,they were 69 percent more likely to develop eczema and 46 percent more likely to be prescribed allergy-related medicines compared to children conceived without fertility treatment.These differences were found to be statistically significant,with adjustment for parental asthma and other risk factors.

　　'Asthma and allergic conditions are some of the most common chronic diseases affecting children,'Dr Edwina Yeung,of the National Institute of Child Health and Human Development in Bethesda,Maryland and senior author of the study told the Daily Mail.'An important research direction to pinpoint a mechanism will be to clarify and unravel the impacts of fertility medications or procedures themselves from underlying subfertility.'

　　Dr Yeung and her fellow researchers studied 5034 mothers,across 57 New York counties,and their 6171 children born between 2008 and 2010.Within the middle of their childhood 2056 children had taken part in a follow-up questionnaire to see if asthma or any allergies persisted.Fertility treatments that any mothers underwent,including IVF,and ovulation induction(via oral or injectables).

　　This study has indicated a potential link of a shared biological outcome between the fertility treatments,and the children conceived from using them,developing asthma.Although the mechanism is unknown,researchers theorised that this may have caused the conceived fetus to experience hormone levels outside the normal physiological range.However,researchers also speculate that those mothers who underwent fertility treatment may be more likely to receive diagnoses from physicians on behalf of their children.This could be due to their higher socioeconomic background or because they are more likely to seek medical care due to undergoing previous fertility treatments.

　　'Until we have a better understanding of an underlying mechanism,the implications for clinical practice are limited,'Dr Kristen Polinski first author of the study told Healio.

　　The authors have suggested that additional studies are needed,which are necessary to conclude how fertility treatment,or parental infertility,may result in their children presenting a higher risk for asthma and allergies.