這項(xiàng)發(fā)表在PLOS Medicine上的研究招募了300多名年齡在18-40歲之間的女性，她們至少有一年的原因不明不孕和排*規(guī)律，并且體重指數(shù)(BMI)為30或以上。BMI被用作一種篩查工具，以確定一個(gè)人的體重是否與身高相關(guān)。

　　患者被隨機(jī)分為兩組。一組接受減肥方案，包括增加體力活動(dòng)、限制卡路里的飲食和抗肥胖藥物。這導(dǎo)致平均體重減輕了7%。對(duì)照組不指導(dǎo)減肥，但增加了體力活動(dòng)。

　　這些變化持續(xù)了16周。在此期間未自然受孕的患者接受了最多三個(gè)周期的*巢刺激和宮腔內(nèi)人工授精的生育治療。該過(guò)程涉及將精子直接輸送到子宮中以增加受精成功率。

　　雖然與對(duì)照組相比，減肥組的活產(chǎn)成功率并沒(méi)有增加，但一些健康指標(biāo)確實(shí)有所改善，例如血壓降低和腰圍減小。

　　這組作者說(shuō)，這些發(fā)現(xiàn)建立在其他研究中越來(lái)越多的證據(jù)的基礎(chǔ)上，即肥胖或超重女性在接受生育治療之前的孕前減肥對(duì)提高活產(chǎn)率沒(méi)有好處。

　　英國(guó)生育協(xié)會(huì)負(fù)責(zé)人Raj Mathur博士并沒(méi)有參與這項(xiàng)研究，他告訴MailOnline，“這項(xiàng)研究確實(shí)鼓勵(lì)我們研究計(jì)劃IVF治療的患者的結(jié)果，以及是否有理由將BMI嚴(yán)格限制在30 NHS資格目的。

　　原文：Losing weight prior to fertility treatment may not increase obese women's chance of having a baby,according to new research.

　　A US study found no significant differences in the rate of healthy live births in obese women who lost weight before undergoing fertility treatment,compared to a control group.

　　'Although it differs from current clinical standards of care,there's just not enough evidence to recommend preconception weight loss in women with obesity and unexplained infertility,'said lead author Professor Richard Legro,at the Pennsylvania State College of Medicine in Hershey,Pennsylvania.

　　The study,published in PLOS Medicine,recruited over 300 women aged 18-40 years old,who had at least one year of unexplained infertility and regular ovulation,and whose body mass index(BMI)was 30 or above.BMI is used as a screening tool to determine if an individual has a healthy weight in relation to their height.

　　The patients were randomised into two groups.One group was put on a weight-loss regimen comprising increased physical activity,a calorie-restricted diet and anti-obesity medication.This resulted in an average weight loss of seven percent.The control group were not guided to lose weight but did increase physical activity.

　　These changes were in effect for 16 weeks.Patients who did not conceive naturally during this time were given fertility treatment of up to three cycles of ovarian stimulation and intrauterine insemination.This procedure involves the sperm being delivered directly into the uterus to increase fertilisation success.

　　Whilst the weight-loss group did not have increased success in resulting live births compared to the control group,some indicators of health did improve such as lowered blood pressure and a decrease in waist size.

　　According to the authors,these findings build on the increasing evidence from other studies that preconception weight loss for obese or overweight women before undergoing fertility treatment bears no benefit in improving live birth rates.

　　Dr Raj Mathur,head of the British Fertility Society and not involved in the study,told MailOnline,'This study does encourage us to look at the outcome in patients planning IVF treatment,and also whether a rigid cut off BMI of 30 is justified for NHS eligibility purposes.'