在生育路上，大家或多或少都會(huì)遇到一些難題，今天我們翻譯了CEF大咖，——美國(guó)試管嬰兒教父Rizk教授的關(guān)于當(dāng)今輔助生育技術(shù)現(xiàn)存爭(zhēng)議。
美國(guó)試管嬰兒教父Botros Rizk，M.D，作為CFG全球醫(yī)療總監(jiān)，同時(shí)也是CEF創(chuàng)始人、院長(zhǎng)。他師從諾貝爾獎(jiǎng)得主試管嬰兒之父Robert Edwards，有40年執(zhí)業(yè)從醫(yī)經(jīng)驗(yàn)，參與過(guò)10000+試管案例。
There were numerous previous statistics showing frozen embryo transfers have higher pregnancy rates than those of fresh embryos transfers.Therefore,people start to think that freeze-all policy applies to every situation and every single patient regardless of their different characteristics.However,Dr.Rizk delivered a speech themed“Controversy in ART”on the symposium at the 75th ASRM.
以往有大量的數(shù)據(jù)顯示凍胚移植比鮮胚移植的成功率高，因此人們認(rèn)為凍胚移植適用于所有類(lèi)型的病人。然而，第75屆ASRM大會(huì)當(dāng)天，Dr.Rizk教授出席了學(xué)術(shù)座談會(huì)，并發(fā)表了以“當(dāng)今輔助生育技術(shù)現(xiàn)存爭(zhēng)議”為主題的演講。
Controversy現(xiàn)存爭(zhēng)議
However,the truth is that freezing of all embryos in In Vitro Fertilization(IVF)is beneficial in high responders,but not intermediate and low responders who are of better outcome with fresh embryo transfers.The Meta-Analysis has divided patients into three groups.
Poor responders:1-5 eggs retrieved;
Intermediate responders:6-14 oocytes retrieved;
High responders:15+oocytes retrieved.
實(shí)際上，凍胚移植對(duì)于促排反應(yīng)較好的病人來(lái)說(shuō)較為有利;對(duì)于促排反應(yīng)一般和較差的病人來(lái)說(shuō)，鮮胚移植更適合。Meta分析研究把所有的病人分為了三組：
促排結(jié)果較差：取*數(shù)1-5顆;
促排結(jié)果一般：取*數(shù)6-14顆;
促排結(jié)果良好：取*數(shù)15顆或以上。
Meta-Analysis(Meta分析法)：
There were total of 82,935 cycles completed,composing 69,102 fresh transfers,and 13,833“freeze all”followed by FET.
調(diào)研共由82,935個(gè)周期組成，其中包含69,102個(gè)鮮胚移植周期，及13,833個(gè)凍胚移植周期。
Conclusions(結(jié)論):
The conclusions can be drawn from the comparisons as listed in the graphics down below(green stands for Fresh Embryo Transfer,aka Fresh ET;while blue stands for Frozen Embryo Transfer,aka FET)：
從下列對(duì)比圖表中，可得出如下結(jié)論(綠色*表鮮胚移植，藍(lán)色*表凍胚移植)：
1.Freeze-all strategy is beneficial for pregnancy outcomes in high responders(15+oocytes retrieved),while for patients who are intermediate and poor responders,fresh transfer tend to be a better option;
數(shù)據(jù)表明，促排結(jié)果良好的病人更適合凍胚移植,促排結(jié)果一般和較差的病人更適合鮮胚移植;
2.In intermediate(6-14 oocytes retrieved)and low(1-5 oocytes retrieved)responders,clinical pregnancy and live birth rates are higher following fresh embryo transfer;
數(shù)據(jù)表明，促排結(jié)果較差和一般的病人鮮胚移植的臨床妊娠率和嬰兒活產(chǎn)率相比凍胚移植更高;
3.Birthweights are higher after FET vs fresh ET in infants born to high and intermediate responders.
數(shù)據(jù)表明，促排結(jié)果一般和良好的病人凍胚移植所誕生的嬰兒初生重相比鮮胚移植更高。更多干貨分享，敬請(qǐng)關(guān)注我們的直播。
溫馨提示：我們是USIB美中橋，如需要了解更多試管嬰兒資訊，請(qǐng)掃一掃下方二維碼關(guān)注“USIBIVF”,以及關(guān)注美中橋“USIBIVF”公眾號(hào)，即時(shí)獲取更多的試管嬰兒資訊。
發(fā)表于2021-06-29 16:14:59
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美國(guó)試管嬰兒教父Botros Rizk，M.D，作為CFG全球醫(yī)療總監(jiān)，同時(shí)也是CEF創(chuàng)始人、院長(zhǎng)。他師從諾貝爾獎(jiǎng)得主試管嬰兒之父Robert Edwards，有40年執(zhí)業(yè)從醫(yī)經(jīng)驗(yàn)，參與過(guò)10000+試管案例。
There were numerous previous statistics showing frozen embryo transfers have higher pregnancy rates than those of fresh embryos transfers.Therefore,people start to think that freeze-all policy applies to every situation and every single patient regardless of their different characteristics.However,Dr.Rizk delivered a speech themed“Controversy in ART”on the symposium at the 75th ASRM.
以往有大量的數(shù)據(jù)顯示凍胚移植比鮮胚移植的成功率高，因此人們認(rèn)為凍胚移植適用于所有類(lèi)型的病人。然而，第75屆ASRM大會(huì)當(dāng)天，Dr.Rizk教授出席了學(xué)術(shù)座談會(huì)，并發(fā)表了以“當(dāng)今輔助生育技術(shù)現(xiàn)存爭(zhēng)議”為主題的演講。
Controversy現(xiàn)存爭(zhēng)議
However,the truth is that freezing of all embryos in In Vitro Fertilization(IVF)is beneficial in high responders,but not intermediate and low responders who are of better outcome with fresh embryo transfers.The Meta-Analysis has divided patients into three groups.
Poor responders:1-5 eggs retrieved;
Intermediate responders:6-14 oocytes retrieved;
High responders:15+oocytes retrieved.
實(shí)際上，凍胚移植對(duì)于促排反應(yīng)較好的病人來(lái)說(shuō)較為有利;對(duì)于促排反應(yīng)一般和較差的病人來(lái)說(shuō)，鮮胚移植更適合。Meta分析研究把所有的病人分為了三組：
促排結(jié)果較差：取*數(shù)1-5顆;
促排結(jié)果一般：取*數(shù)6-14顆;
促排結(jié)果良好：取*數(shù)15顆或以上。
Meta-Analysis(Meta分析法)：
There were total of 82,935 cycles completed,composing 69,102 fresh transfers,and 13,833“freeze all”followed by FET.
調(diào)研共由82,935個(gè)周期組成，其中包含69,102個(gè)鮮胚移植周期，及13,833個(gè)凍胚移植周期。
Conclusions(結(jié)論):
The conclusions can be drawn from the comparisons as listed in the graphics down below(green stands for Fresh Embryo Transfer,aka Fresh ET;while blue stands for Frozen Embryo Transfer,aka FET)：
從下列對(duì)比圖表中，可得出如下結(jié)論(綠色*表鮮胚移植，藍(lán)色*表凍胚移植)：
1.Freeze-all strategy is beneficial for pregnancy outcomes in high responders(15+oocytes retrieved),while for patients who are intermediate and poor responders,fresh transfer tend to be a better option;
數(shù)據(jù)表明，促排結(jié)果良好的病人更適合凍胚移植,促排結(jié)果一般和較差的病人更適合鮮胚移植;
2.In intermediate(6-14 oocytes retrieved)and low(1-5 oocytes retrieved)responders,clinical pregnancy and live birth rates are higher following fresh embryo transfer;
數(shù)據(jù)表明，促排結(jié)果較差和一般的病人鮮胚移植的臨床妊娠率和嬰兒活產(chǎn)率相比凍胚移植更高;
3.Birthweights are higher after FET vs fresh ET in infants born to high and intermediate responders.
數(shù)據(jù)表明，促排結(jié)果一般和良好的病人凍胚移植所誕生的嬰兒初生重相比鮮胚移植更高。更多干貨分享，敬請(qǐng)關(guān)注我們的直播。
溫馨提示：我們是USIB美中橋，如需要了解更多試管嬰兒資訊，請(qǐng)掃一掃下方二維碼關(guān)注“USIBIVF”,以及關(guān)注美中橋“USIBIVF”公眾號(hào)，即時(shí)獲取更多的試管嬰兒資訊。